The Tuskegee Experiment Essays - Syphilis, , Term Papers

The Tuskegee Experiment ?The Tuskegee Experiment? In 1932, in the area surrounding Tuskegee, Macon County, Alabama, the United States Public Health Service (PHS) and the Rosenwald Foundation began a survey and small treatment program for African-Americans with syphilis. Within a few months, the deepening depression, the lack of funds from the foundation, and the large number of untreated cases provied the government's reseachers with what seemed to be an unprecedented opportunity to study a seemingly almost ?natural? experimentation of lantent syphilis in African-American men. What had begun as a ?treatment? program thus was converted by the PHS reasearchers, under the imprimatur of the Surgeon General and with knowledge and consent of the Prewsident of Tuskegee Institute, the medical director of the Institute's John A. Andrew Hospital, and the Macon County public health officials, into a persecpective study-The Tuskegee Study of Untreated Syphilis in the Negro Male (Jones1-15). Moreover, the Tuskegee Syphilis Study, which began in 1932 and was terminated in 1972 by the protest of an enraged public, constituted the longest nontherapeutic experiment on human beings in medical history. Since the premise on which the experiment was based did not involve finding a cure or providing treatment, the question then remains why did the study begin and why was it continued for four decades? In Bad Blood: The Tuskegee Syphhilis Experiment, James Jones describes the fate of the 600 Black victims. Ultimately, 399 men, who were in the late or tertiary stages of syphilis, participated in the experiment. In addition, 201 men who were free of the disease were in cluded in the study. Both groups of men were neither told the truth about their ailment or lack thereof, nor were they informed that they were part of a medical study. Medical personnel assured the subjects that they were suffering from ?bad blood,? a euphemism that in the local parlance, reffered to many ailments. None of the men knew that the ?bad blood? which coursed through their veins was contagious. None understood how the disease was transmitted; no one explained to them that congenital syphilis was passed on from female to fetus. It was an experiment based on deception, a characteristic that it retained for the next forty years. Through a historical analysis of the experiment several questions arise, particular ly the issues of the men's participation in the experiment and the black professionals who witnessed the study. Why did these Black men take part in this study? Why did the Black healtth professionals not challenge the study? The answers to these questions are interconnected and lies captive in a term Jones calls racial medicine (Jones 15). Prior to 1932 information concering the origin, conception, developement, and the complications of untreated syphilis was known to medical science. The one element left to be known about this diease was a cure. By this time, scientist were well aware of the fact that syphilis was a highly contagious diease caused by treponema pallidum, a microscopic organism resembling a corkscrew. The disease may be acquired, meaning passed from person-to-person either during sexual intercourse or mixing of bodily fluids, or congenital meaning obtained through birth. The disease progresses in three stages: primary, secondary, and tertiary. The characteristics for the first two stages exhibit chancre sores, various mild rashes, bone and joint pain, as well as cardiac palpitations. Following the secondary stage is a period of latency where all symptoms associated with syphilis disappear, a period that may last from a few weeks to thirty years. At this time, delusion of health is shattered and the symp toms revisit with a harsher intensity. It is at the tertiary stage that the majority of the damage is done. Tumors begin to coalesce on the skin forming huge ulcers covered with a crust of dried exuded matter. Bones are attacked by tumors and in some cases eaten entirely away. The tumors also attack the walls of the heart or blood vessels causing aneurysms, balloon like sacs filled with blood. If the aneurysm burst, death is instantaneous. Syphilis can attack the brain in a condition known as paresis, in which the brain softens and produces paralyis and insanity. Optic nerves can be attacked causing blindness or inflicting deafness (Jones 2-4). The progression of th de

America and its Past war economy essays

America and its Past war economy essays There is very little doubt that a true war is one of the most economically sound events in which a government could participate. War is good for business. Excluding the enormous cost of life and other social and political ramifications, war is one of the best things that can happen to a society. Both Malthaus and Marx argue that capitalist societies require war to survive and expand. Throughout history there are many examples of how wars have stimulated economies and created new avenues of development for industry. In fact much of the development of countries such as the United States, happened during and directly after wars. Erik Janeway insists that War had been the direct and immediate cause of Americas cycles of expansion. War has become an increasingly good opportunity for businesses and government. This was particularly so after the employment of Keynes economic theories in World War Two. Keynes suggested that in order to stimulate an economy, there must be an increase in deficits. After this increase in deficits, more and more employment will be created, spending will increase and the wealth and more importantly industry of the country will increase. This is actually the basic model of a wartime economy. As soon as a government becomes aware of a conflict or a threat to national security, it begins to allocate large amounts of money to weapons and other defence measurements. Demand for weaponry and defence machinery is usually greater than peacetime arms industry can cope with, and expansion of industry occurs, and naturally the rate of unemployment drops. There is also room for technological development, as the government is evidently eager to create newer, more technologically advanced weaponry that will destroy the enemy. With so much extra spending, wartime economies begin to boom. More people are in employment, not only through industry expansion but also throu...

IT POLICY Essay Example | Topics and Well Written Essays - 750 words

IT POLICY - Essay Example The three main ethical questions that the use of social networks as a mean of communication are: (1) do social networks protect individual privacy of the users? (2) Do social networks ensure safety for their users? (3) Do the advantages of using social networks outweigh the disadvantages? The question of whether or not social networks protect individual privacy of the users is a pertinent ethical question because a critical look at many social networks shows that the use of social networks comprise individual privacy of the user. This is because many users of social networks, especially the youth share important private information about themselves with their friends on social networks, without realizing that people with bad motives can use the private information to harm them in one way or another. The question of whether or not social networks ensure safety for their users is also a critical ethical question. This question is particularly important considering cybercrimes like cyber bullying and cyber stalking. The third question also is very important because, although there are many advantages of using social networks as a mean of communication, there are also many disadvantages of using social networks as a mean of communication. On utilitarian grounds, therefore, it is important to determine whether or not the advantages of using social networks outweigh the disadvantages. To begin with, social networks compromise individual privacy, especially among the teenagers who disclose a large amount of their personal information online. As Christofides has rightly argued, although Facebook has played a significant role in telecommunication, it has presented a problem in privacy protection among high school students, thus doing more harm than good (2010). Many teenagers disclose on social networks like Facebook sensitive personal information like relationship status, email address, the list of their friends’ birthdays, as well as  other

Describe how a project manager might achieve effective project Essay

Describe how a project manager might achieve effective project management Refer to project team issues considered in the lecture notes - Essay Example oject management, the most important factor to be considered is that all project managers are tasked to accomplish the goals and objectives of their projects. This paper would identify how a project manager could be successful in project management or, more specifically, in effectively completing a project. First, it is important to stress that a project manager is crucial in ensuring the success of a project in the sense that he orchestrates the multiple components and stakeholders involved. He or she must plan the project and at the same time oversee disparate groups, watch for cost overruns, mediate disputes, among other tasks that require balancing. In short, a project manager must deal with several issues including time, cost, people, equipment, resources, commitment and so forth all at the same time. An effective project manager could navigate these issues by systematically addressing them in planning, organizing, staffing the project and facilitating the work. Planning is one of the most important responsibilities of a project manager. If it is performed correctly, then the entire project could run smoothly to the point that it could even run itself. According to Turner (1992), project management is the endeavour in which human, material and financial resources are organized in a novel way so as to achieve unitary and beneficial change. In this context, the project manager’s skill in planning is underscored. According to Harold Kerzner (2009), the project manager, as the architect of the project plan, must provide: the complete definition of tasks, resource requirement of definitions; major timetable milestones; definition of end-item quality and reliability requirements and the basis for performance management. (p. 19) The rationale for such requirements is that, when met, they could result to the assurances that stakeholders involved understand their responsibilities and those problems that could arise from scheduling and the allocation of resources

Rising Tuitions are Keeping Many Students Out of College Essay

Rising Tuitions are Keeping Many Students Out of College - Essay Example The researcher states that while the rising costs of college tuition are due to a number of different factors, the result is that fewer think they can afford it, especially since degrees from non-prestige universities or less technical degrees are simply not valued as in the past. Grant used to cover far more than now, so more financial aid becomes debt. Even well informed students, who know their actual cost after scholarships may balk at incurring such high debt. It is a fact that tuition has far exceeded inflation and wages have not kept up for middle and low income families In light of the tremendous burden the debt load would become, many students will elect to get jobs and train as they go up the corporate ladder. Rising tuitions are definitely keeping more students out of college than ever before. In looking at the documented raises in tuition over the past twenty years, wages have not kept pace. This means the burden on the family will be proportionately higher. In addition, financial aid grants cover less than before, leaving the balance to be covered by loans. Some institutions perceive the extension of financial aid as an inducement to raise their tuition. In addition, the tuition is no longer carved in stone, as most universities offer scholarships to accepted students, thereby reducing the cost. To conclude, it is evident that the better quality they perceive the student, the higher the scholarship will be. This allows colleges to filter out some applicants in preference for others.

Dopamine Neuron Characteristics

Dopamine Neuron Characteristics Said Mohammed Al Hakmani The question of this assignment Discuss the characteristics of a dopamine neuron and how does this relate to what has been achieved in the culture dish. Introduction In our body a lot of organs that make our function of movement and control. Parkinson’s disease affect our move. It happen when there is a problem of the certain of nervous cells in the brain. The nerve cells make an important chemical is named dopamine. The dopamine sends signals to the part of the brain that controls movement. Also, the dopamine lets the move of our muscle smoothly. The Parkinson’s disease breakdown the nerve cells that make the dopamine. When the person do not have enough dopamine the problem of move can start and the person cannot control the way where to move. (1) Figure 1 shows the nerve cells in the brain (1) The Parkinson’s disease is progressive, which means it gets worse over time. But this happen slowly many years. Until now no one know what acutely makes the nerve cells breakdown. However, scientists are doing a lot of research to know the reason of the cells breakdown. Some study say Parkinson disease is gene abnormal in some people but so far there is enough proof to show that its always inherited.(1)Braak’s hypothesis proposes that the Parkinson’s disease begins in the digestive tract and in the brain’s centre of smell. The theory is supported by the fact that symptoms associated with digestion and smell happen very early on the disease. Professor Jia- Yi Lis research team has now been able to tack this process further, from the gut to the brain in rat models. The experiment shows how the toxic protein alpha-synculein is transfer from one cell to another before reaching the brain’s movement centre, giving increase to the characteristic of movemen t in the Parkinson’s disease. He prove that disease process actually can travel from the peripheral nervous system to the central nervous system, in this case from the wall of the gut to the brain.(3) Usually people start to have symptoms of Parkinson’s disease between the ages of 50 and 60. But in certain case start earlier. The symptoms of Parkinson’s disease first may be notice is tremor which means shaking or trembling. And these may affect the hands, arms, or legs. It is one of the most common signs but not everyone has it. Also, not everyone with a tremor has Parkinson’s disease. The tremor often starts only one side of the body or just one arm or leg. In addition, Parkinson’s affects the stiff muscles all through the body, so it causes problems like trouble swallowing or constipation. In the later stages of Parkinson’s disease a person may have fixed expression trouble speaking and other problems. Some people lose mental skills. (1) A dopamine Dopamine is a chemical signal that transfers information from one neuron and the next neuron. It released the signals from the first neuron and it floats into the synapse (the space between the two neurons) to the second neuron. The receptors bumps the signals down to the receiving neurons. The dopamine interested in many different important pathways and it known as the mesolimbic pathways which starts with cells in the ventral tegmental area in the midbrain.(2) The dopamine plays numbers of roles in human and other animals. It controls many functions such as movement, memory, pleasurable reward, attention, sleep, learning, mood, inhibition of prolactin production, and behaviour. The increase and deficiency of this dopamine chemical is cause of several disease like Parkinson’ disease. In the brain, part called the basal ganglia regulates movement. Basal ganglia in turn depend on a certain amount of dopamine to function. The action of this occurs by dopamine receptors D 1-5. Th e deficiency in dopamine in the brain may become delayed and uncoordinated the movement and other function of the body. (3) The dopamine is important neurotransmitter in the brain substantial part of the overall dopamine in the body is produced outside the brain by mesenteric organs. The production of dopamine within the central nervous system, depend on the dopamine biosynthesis. There are two steps of dopamine biosynthesis takes place in the cytosol of CAergic neurons and starts with hydroxylase of L-tyrosine at the phenol ring by tyrosine hydroxylase to produce DOPA.(4) Stem cell The stem cell have potential to develop into many different cell types in the body during early life and growth. In many tissues they serve as a sort of internal repair system, divided without limit to replace other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the ability either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell and other cells.(5) The stem cells are featured from other cell types by two important characteristics. First, they are capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under some physiologic or experimental conditions, stem cell can be become tissue- or organ-specific cells with special functions. In certain organs, such as the gut and bone marrow, they regularly divide to repair and replace worn out or damaged tissues. In addition, in other organs, such as the pancreas and the heart, stem cells only divide under special conditions. (5) Scientists primarily worked with two types of stem cells from animals and humans: embryonic stem cells and non-embryonic somatic or adult stem cells. In 1981 Scientists discovered ways to derive embryonic stem cells from early mouse embryos nearly 30 years ago. In 1998 the detailed study of the biology of mouse stem cells led to the discovery. After that method to derive stem cells from human embryos and grow the cells in the laboratory. These cells are called human embryonic stem cells. The embryos used to studies were created for reproductive purposes through in vitro fertilization procedures. When they were no longer needed for that purpose, they were donated for research with the informed consent of the donor. Researchers made another breakthrough by identifying conditions that would allow some specialized adult cells to be reprogrammed† to assume a stem cell-like state in 2006. This new kind of stem cell, called induced pluripotent stem cells (iPSCs). (5) The Stem cells are important for living organisms for different reasons. In the three to five days old embryo, called a blastocyst, the inner cells give rise to the en tire body of the organism, include all of the many specialized cell types and organs such as the, lungs, heart, skin and other tissues. In certain adult tissues, such as bone marrow, brain, and muscle, the adult stem cells generate replacements for cells that are lost through normal injury, or disease. The stem cells make new potentials for treating diseases such as heart disease and Parkinson disease. However, much work remains to be done in the laboratory to understand how to use these cells therapies to treat disease.(5) Research on stem cells continues to advance about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. The stem cell research is one of the fascinating areas in contemporary biology.(5) The laboratory of human embryonic stem cell The protocol of the laboratory that culture the stem cells must contain special equipment use to avoiding the contamination during make the HESC culture. The equipment that are use a CO2 incubator, that cannot use the detergent to clean use 70% of ethanol to get the best result to control the contamination. Used a biocontainment hood to control of microorganisms. A microscope with phase contrast optics to see the cell and colony morphology. A refrigerator 20Ć¹ and freezers 80Ć¹.Use the liquid nitrogen freezer to store the stocks of HESC and feeders. Also, need small water bath 37 Ć¹ to thawing the cell that are frozen.(6) Feeder culture The feeder culture use to growth of HESC. It prepare primary fibroblast that come from the CF-1 mice. The CF-1 mouse embryonic fibroblasts give the optimal growth of HESC without differentiation and recommended for many reason such as function well making feeder, available and cheaper. (6) The methods culture HESC The first thing need to culture the HESC is good feeder. Human embryonic stem cell should be passaged when the colonies reach size 300 to 500 cells. The plate should be passaged large culture of colonies. The cell always passaged to the plate of feeder cell less than seven days. (6) The materials that required for passaging Human embryonic stem cell are ESC medium, 15 ml centrifuge tubes, calcium/magnesium free PBS, collagenase type IV, cell scraper ,10 cm plates and 0.1% gelatin.(6) The procedure: Table show the methods of passaging HESC adopted steps only but I create the table (6) Growth of the HESC To growth the human embryonic stem cell transfer cell from preimplantation stage embryo to the culture dish. The cell will grow on the culture dish and will spread and divided on the surface of the media. The culture dish contain the mouse embryonic cell which provide the nutrients into the culture media to growth the cell. However, researcher now devised to grow the embryonic stem cells without mouse feeder cells to avoid the risk viruses that can transfer from the media to the human. (5) The test use to identify embryonic stem cells in the laboratory. There is no standard test approved yet to the scientists who study human embryonic stem cells. However, the laboratories that grow the human embryonic stem cells use different types of test such as: Growing and subculture of the stem cell for many months to make sure the health of the cell. Use techniques to determine the presence of transcription factors that produced by undifferentiated cells. These are two important transcription factors Nanog and Oct-4. The both factors help the genes to turn on and off to make maintain the stem cell to undifferentiated and self-renewal.(5) The GMP There are many challenges to use the stem cells for replacement therapy. However, the good manufacturing practice (GMP) is quality assurance system that use to make sure the product of stem cells is good and safe to use for treatment. The GMP in human embryonic stem cell culture required several components for good clinical practice. First, the culture or the feeder media that use in the laboratory must be reach to standard of GMP. Second, the inner cell mass of the blastocyst and passaging of the cell. Final, all components of the culture and cryopreservation media should validated to the GMP system. (7) The ethical issue surrounding the use of embryonic cell need be carefully controlled. In UK human embryonic stem cell can collected from left over embryos produced as part of vitro fertilisation. This can done under strict UK guidelines from Human Fertilisation Embryology Authority and only in the early stage embryos can be use in research up to maximum of 14 day of development.(8) The power of stem cell In 1980, the researcher take stem cell inside the developing embryos and growth in the laboratory to make the human embryonic stem cell. However, the adult stem cell are extremely powerful and easier for researcher to make embryonic stem cell and can converted into any type of cell in the body. But there is risk that the stem cell may grow uncontrolled in the body which cause to formation of tumour.(8) Scientist in Japan worked to make stem cell from normal adult cell in 2006 and this called induced pluripotent stem cell (iPS). This iPS cell in the future may use to make for the patient own cell and it be safe from other factor the affect the patient. The researcher attempted to treat the cell that are die from the nervous cell by make experiment on rat and mice. It show improvement to develop of dopamine that make replace of nervous cell. The researcher can measure the increase of dopamine neuron function in striatum of the patient by using positron emission tomography that make image of the brain.(5) Many researchers believe that embryonic stem cell could be excellent source of dopamine neurons because can grow in culture dish and make into any type of cell after long time in culture. Now, the dopamine neurons have been generated from the Human embryonic stem cell. One study research use the special type of companion cell with specific growth factors to promote the differentiation of the embryonic stem cell through several stages into dopamine (5) References Webmd.com, (2014). Parkinsons Disease Center: Symptoms, Treatments, Causes, Tests, Diagnosis, and Prognosis. [online] Available at: http://www.webmd.com/parkinsons-disease [Accessed 15 Nov. 2014]. Slate Magazine, (2014). Slate Magazine Politics, Business, Technology, and the Arts. [online] Available at: http://www.slate.com [Accessed 16 Nov. 2014]. News-Medical.net, (2014). Health News and Information News Medical. [online] Available at: http://www.news-medical.net [Accessed 16 Nov. 2014]. Meiser, J., Weindl, D. and Hiller, K. (2013). Complexity of dopamine metabolism. Cell Commun Signal, 11(1), p.34. Stemcells.nih.gov, (2014). NIH Stem Cell Information Home Page. [online] Available at: http://stemcells.nih.gov [Accessed 16 Nov. 2014]. Stemcell.umn.edu, (2014). Home MED Stem Cell Institute, University of Minnesota. [online] Available at: http://www.stemcell.umn.edu [Accessed 20 Nov. 2014]. Unger, C., Skottman, H., Blomberg, P., Sirac Dilber, M. and Hovatta, O. (2008). Good manufacturing practice and clinical-grade human embryonic stem cell lines. Human Molecular Genetics, 17(R1), pp.R48-R53. Stem cells the story so far. (2014). progress the research magazine of Parkinsons UK, (15 summer).

Literary Devices in Carvers Cathedral Essay -- Raymond Carver, irony

Upon reading Raymond Carver's short story of the Cathedral one will notice the literary devices used in the short story. When analyzing the story completely, one then understands the themes, motifs, metaphors, and the overall point of the piece. This leaves the reader with an appreciation of the story and a feeling of complete satisfaction. Carver tells the story in first person of a narrator married to his wife. Problems occur when she wants a friend of hers, an old blind man, to visit for a while because his wife has died. The narrator's wife used to work for the blind man in Seattle when the couple was financial insecure and needed extra money. The setting here is important, because Seattle is associated with rain, and rain symbolically represents a cleansing or change. This alludes to the drastic change in the narrator in the end of the story. The wife and blind man kept in touch over the years by sending each other tape recordings of their voices which the narrator refers it to being his wife's "chief means or recreation" (pg 581). The narrator does not move chronologically, contrarily, but uses small flashbacks to tell his point, leading up to the actual visit of the blind man where he then tells the story in a present tense. This lets the author seem like he is actually telling the story in person, reflecting on past occurrences of his life when necessary. His tone however, is a cynical, crude, humorous tone that carries throughout the story. The word choice and sentences are constructed with simple, lifelike words, which makes the reader sense the author is really telling the story to them. The narrator is biased against the blind from the beginning. For instance, he stereotypes all blind people thinking they ... ...irst time for everything." However, because of the way her "inhaled" and "held in the smoke", the narrator believes he has been "doing it since he was nine years old" (pg. 506). This alludes to Robert's childhood, another thing the narrator and him share. Hence, upon analyzing the story, one can conclude the certain themes that parallel through the pages. Firstly, a theme of unity and trust is present at the end of the play. This is supported by the image of the cathedral, which is a place of unity. Most importantly, the notion of equality among people is the main theme within this story. The narrator starts as a biased, idiot, who dislikes all people that are not like himself. He even at times is rude to his wife. Ironically, it takes a blind man to change the man that can literally see, to rule out the prejudices and to teach him that all men are created equal.